合成ペニシリンTicarcillinにかんする細菌学的評価
1977 年 25 巻 9 号 p. 2404-2421
詳細
1977 年 25 巻 9 号 p. 2404-2421
The in vitro and in vivo antibacterial activity of ticarcillin (TIPC) was compared with that of carbenicillin (CBPC) and sulbenicillin (SBPC). The following results were obtained.
1) The antibacterial spectrum of TIPC was similar to that of CBPC and SBPC.
2) The in vitro antibacterial activity of TIPC against clinical isolates of Staphylococcus aureus, E. coli, Proteus species, Klebsiella pneumoniae, Serratia marcescens and Pseudomonas aeruginosa was similar to that of CBPC and SBPC.
3) Influence of medium pH, horse serum protein and inoculum size on in vitro antibacterial activity of TIPC showed the same tendency to CBPC and SBPC.
4) Pattern of development of resistance on TIPC in vitro was similar to that of CBPC and SBPC.
5) Bactericidal action of TIPC against E. coli and Pseudomonas aeruginosa appears more rapidly than CBPC.
6) Stability of TIPC to β-lactamase extracted from penicillin resistant E. coli was generally similar to that of CBPC.
7) On the protecting effects for systemic infections in mice, the effect of TIPC was similar to that of CBPC for E. coli and was superior to CBPC for Pseudomonas aeruginosa. The therapeutic efficacy of multiple administration of TIPC was more effective than that of CBPC.
