Ticarcillinのグラム陰性桿菌に対する基礎的検討

抄録

Ticarcillin, a new semisynthetic penicillin, was investigated on the antibacterial activity chiefly against gram-negative bacilli as Ps. aeruginosa derived from blood, and on the combination effect with aminoglycoside antibiotics to compare carbenicillin and sulbenicillin. Results obtained were as follows.
1. Ticarcillin showed stronger antibacterial activity than carbenicillin and sulbenicillin against all species of Ps. aeruginosa, Enterobacter and Serratia.
2. Ticarcillin and gentamicin or dibekacin were found to be synergistically bacteriostatic against all strains of Ps. aeruginosa, the effect being 8-16 times stronger compared with a single administration. Compared with sulbenicillin, ticarcillin was shown to inhibit the growth of Ps. aeruginosa equally to sulbenicillin with 1/2 concentration of sulbenicillin, if concentration of gentamicin was fixed.