A new semi-synthetic penicillin, ticarcillin (TIPC) was investigated in laboratory and clinical field and the followings were obtained.
1) Antibacterial activity
Minimal inhibitory concentration of TIPC was compared with that of carbenicilln (CBPC). As the result, the antibacterial activity of TIPC was parallel with that of CBPC. But, in Ps. aeruginosa, E. coli, Salmonella and Enterobacter aerogenes strains TIPC showed better antibacterial activity than CBPC.
2) Concentration in serum and sputum
The peak of serum concentration was 140.0 and 250. 0 μ/ml respectively following 3.0 g and 6. 0 g drip infusion of TIPC. The half life was 0. 72-0. 78 hour. The peak of the concentration in sputum was 0.7 μg/ml following 6. 0 g drip infusion. And the ratio of serum concentration to sputum one was 0.003.
3) Clinical evaluation in respiratory infections
TIPC was administered to 5 chronic pulmonary infections caused by Ps. aeruginosa and one bronchopneumonia. The daily dose was 3. 0 to 6. 0 g and duration 4 to 22 days. As the results, clinical response was excellent in one, good in 2, fair in one and poor in 2 cases. Ps. aeruginosa in sputum was disappeared in one case. No side effects nor abnormal laboratory findings were observed.
