泌尿器科領域におけるTicarcillinの基礎的, 臨床的検討

抄録

1. Minimal inhibitory concentrations of ticarcillin, carbenicillin (CBPC) and sulbenicillin (SBPC) were determined by the plate dilution method against 48 strains of Ps. aeruginosa isolated from infected urine.
In vitro antibacterial activities of ticarcillin varied with inoculum size. Its activities with 10⁶ cells/ml inoculum size were more potent than 10⁸ cells/ml. With 10⁶ cells/ml of inoculum size, ticarcillin was 2 to 4 times more active than CBPC or SBPC against Ps. aeruginosa, 28 out of 48 strains (58.3%) being inhibited by concentration of 50 μg/ml or less.
2. Ticarcillin was administered parenterally at a dose of 1 g twice a day for 7 days to 10 patients with chronic urinary tract infection.
Results obtained were good in 5 cases, fair in 1 case and poor in 4 cases. The medication was well tolerated with no side effects.