STUDIES ON THE PASSAGE OF ANTIBIOTICS INTO THE LYMPH. I

Studies on the Passage of T-1220 (Piperacillin) into the Thoracic Duct and Renal Hilar Lymph in Dog

Abstract

The passage of T-1220 into the thoracic duct and renal hilar lymph in the, dog was, studied in comparison with other antibiotics, carbenicillin (CBPC) and gentamicin (GM), and the following results were obtained.
1. The passage rate of T-1220 to the thoracic duct lymph was superior to those of CBPC and GM. The maximum thoracic lymph levels of T-1220 and CBPC were obtained 'at 3Q minutes after dosing, while that of GM was obtained at 60-420 minutes.
2. The passage rates of antibiotics used to the renal hilar lymph were higher in order as follows; CBPC>T-1220>GM. The maximum renal hilar lymph levels of T-1220 and GM were obtained at 30 minutes after dosing, while that of CBPC was obtained at 60 minutes. The levels of T-1220 and CBPC decreased at approximately the same rate in both lymph and serum.
3. The thoracic duct and renal hilar lymph levels of T-1220. CBPC and GM did not exceed those of serum.