1978 Volume 26 Issue 4 Pages 508-516
The sensitivity to various antibiotics of 76 strains of H. infiuenzae, isolated from clinical specimens in the Hospital of Teikyo University, was examined by the twofold agar-dilution method.
Furthermore, bactericidal effects of various antibiotics against TK 167 type b strain, isolated from cerebrospinal fluid of a child with meningitis, were studied.
1) Seven penicillins, cefatrizine, chloramphenicol, kanamycin and gentamicin were tested for sensitivity against 76 strains of H. infiuenzae.
2) One ampicillin-resistant strain and one chloramphenicol-resistant strain were found out of the 76 tested strains.
3) New semi-synthetic penicillins, such as piperacillin, mezlocillin and apalcillin (PC-904) were two-to four-fold superior in MICs against H. infiuenzae to ampicillin. But, bactericidal effects of these new penicillins were weaker than that of ampicillin.
4) Chloramphenicol and kanamycin exhibited stronger bactericidal action against TK 167 strain than that of penicillins.
