TOXICITY STUDY ON VICCILLIN S (AN AMPICILLIN-CLOXACILLIN COMBINATION)

Subacute Toxicity of Viccillin S in Female Beagle Dogs

Abstract

Viccillin S, an antibiotic mixture consisting of equal amounts of sodium ampicillin and sodium cloxacillin, was administered intravenously to female Beagle dogs for 30 days at the dosage levels of 50, 100, 200 or 400 mg/kg/day.
(1) Dogs receiving 200 or 400 mg/kg/day showed slight clinical signs, namely, vomiting, vasodilation and increase in heart rate, but these signs were probably related to the drug concentration or infusion speed.
Slight relaxation of the nictitating membrane was seen at all dosage levels.
(2) Histopathological findings and biochemical examinations of blood and urine indicated that there were no definite abnormal effects caused by the drug administration in all groups.
(3) It is concluded that the maximum nontoxic dose is 200 mg/kg/day when Viccillin S is injected intravenously to Beagle dogs for 30 days.