Abstract
The following results were obtained in the clinical and experimental studies on PC-904.
1) Antibacterial activity
The MIC of PC-904 against E. coli, Klebsiella and Psudomonas aeruginosa were measured, then it was revealed that the drug had excellent susceptibility on Pseudomonas aeruginosa.
2) Absorption and excretion
The dose response relationship was obtained between the serum levels and the dosage (250mg and 1000mg) of the given drug intravenously. When 1000mg were administered, the serum levels were 60μg/ml at 30min., 22.5μg/ml at 1 hour, 7.1μg/ml at 2 hours, 1.8μg/ml at 4 hours and 0.5μg/ml at 6 hours after administration. Cumulative urinary recovery rate for 6 hours was around 18%.
3) Clinical results PC-904 was administered at 2g per day to 8 patients respectively, 4 cases of cholecystitis, 2 of pneumonia, 2 of urinary tract infection, and the effect was considered excellent in 5 cases. As far as adverse effects were concerned, skin rashes, fever and elevation of GOT and GPT were observed in 1 case and elevation of GOT was observed in 1 case.
