臨床材料から分離された各種病原細菌に対するSisomicinと他のアミノグリコシッド剤6種の抗菌力の比較
1978 年 26 巻 Supplement3 号 p. 23-35
詳細
1978 年 26 巻 Supplement3 号 p. 23-35
The antibacterial activity of Sisomicin against 957 strains of pathogens isolated from clinical materials was assessed in the Clinical Laboratories of Juntendo University Hospital during 1975 and 1976. Staphylococcus aureus, Staphylococcus epidermidis, Haemophilus influenzae, Escherichia coli, Klebsiella, Enterobacter, Serratia, Citrobacter, Proteus mirabilis, Proteus vulgaris, Proteus morganii, Proteus rettgeri, Proteus inconstans, Pseudomonas aeruginosa, Pseudomonas maltophilia, Pseudomonas putrida, Pseudomonas fluorescens, Flavobacterium meningosepticum, Flavobacterium sp., Alcaligenes and Achromobacter xylosoxidans were tested.The minimum inhibitory concentration (MIC) of Sisomicin was compared with that of Gentamicin, Tobramycin, Dibekacin, Amikacin, Kanamycin and Streptomycin.
Antibacterial activity of Sisomicin against Proteus inconstans, Pseudomonas maltophilia, Flavobacterium and Achromobacter xylosoxidans, was rather weak but very strong against the other pathogens tested.
In its antibacterial activity Sisomicin was much stronger than Kanamycin and Streptomycin and superior to Amikacin. Compared with Gentamicin, Tobramycin and Dibekacin the antibacterial activity of Sisomicin was slightly stronger or similar.
Cross-resistance between Sisomicin and Gentamicin, Tobramycin or Dibekacin was observed in many strains tested.
