最近臨床材料から分離した各種細菌に対するAB-206の抗菌力について
1978 年 26 巻 Supplement4 号 p. 18-26
詳細
1978 年 26 巻 Supplement4 号 p. 18-26
The antibacterial activity of AB-206 was determined for a total of 790 strains of Staphylococcus aureus, Haemophilus infiuenzae, Enterobacter, Proteus (Pr. vulgaris, Pr. mirabilis, Pr. morganii, Pr. rettgeri and Pr. inconstans), Serratia marcescens, Pseudomonas (Ps. maltophilia, Ps. putida, Ps. fiuorescens and Ps. cepacia), Achromobacter xylosoxidans, Flavobacterium (F. meningosepticum, F. sp.), Acinetobacter calcoaceticus and Alcaligenes faecalis isolated from various clinical materials at Clinical Laboratories of Juntendo University Hospital during the period from late 1976 to early 1977, and comparisons were made with that of NA, PA, PPA and other antibiotics in ordinary use.
1) AB-206 was equally active as ABPC against H. influenzae.
2) When compared with GM, AB-206 was more active against flve species of Proteus and Serratia marcescens and almost equally active against Enterobacter.
3) The antibacterial activity of AB-206 against four species of Pseudomonas varied according to the species of the organisms, with rather strong activity against Ps. cepacia and relatively weak activity against the other three species of organisms.
4) Against Acinetobacter calcoaceticus, the antibacterial activity shown by AB-206 was inferior to that of MINO and DOTC and equal to that of GM.
5) Although the antibacterial activity of AB-206 against Achromobacter xylosoxidans was weak, more than half strains of Flavobacterium and Alcaligenes had low MIC of AB-206.
6) When compared with NA, PA and PPA, AB-206 showed higher antibacterial activity against any of the strains tested in this study.
