Laboratory and experimental studies on tobramycin were performed, and the following results were obtained:
1) Antibacterial activity
The sensitivity of 70 strains of Pseudomonas aeruginosa isolated from burn wounds to tobramycin was measured, and compared with that to gentamicin and dideoxykanamycin B.
Generally, in MIC values, the antibacterial activity of tobramycin was superior to that of gentamicin and dideoxykanamycin B.
2) Tissue concentration
After a single intramuscular injection of 5 mg tobramycin/kg to rabbits, the concentration of tobramycin in the serum and in the skin were determined.
The peak of concentration in the serum was obtained after 30 minutes (average 186.6μg/ml). On the other hand, the peak of concentration in the skin was obtained after 60 minutes (average 28.0μg/ml). The tobramycin level in the skin was about 20% of that in the serum.
