抄録
1) Antibacteriological effect
The MIC of Cefsulodin (SCE-129, CFS) against P. aeruginosa showed the peak of susceptibility at 6.25μg/ml with 108/ml of inoculated bacteria and at 3.12μg/ml with 106/ml. It has a higher superiority when compared with Carbenicillin or Ticarcillin and similar to that of GM.
2) Absorption and excretion
This was compared in patients between normal and abnormal kidney function. In the patients with normal kidney function, blood concentration revealed the peak at 16μg/ml within 30 minutes after intraveneous injection with t1/2 of 11/2 hour. Urinary concentration showed 1, 000μg/ml within one hour and excretion rate was 67.6% after six hours. In the patients with abnormal kidney function, to whom 500 mg was administered, blood concentration was higher than normal patients with slower curve in excretion. T1/2 was also prolonged and urinary concentration was more than 1, 000μg/ml within an hour. Its recovery rate in urine was 56.7%. In the same group of patients to whom 250 mg was administered, the highest blood concentration was observed between 30 minutes and 4 hours with its peak between 15 and 7.9μg/ml. Urinary concentration was low with mean value of 500μg/ml. Recovery rate in urine was also delayed with a value of less than 40%. No cumulative tendency was observed in multiple dose study for the patients with abnormal kidney function.
3) Clinical results
General clinical effect revealed no case of markedly effective, 2 cases of effective, and 9 cases of noneffective. Bacteriological effect revealed one strain of vanishment, 5 strains of replacement by newly substitute and 5 strains of persistence among 11 strains of P. aeruginosa.
4) The correlation among MIC of CFS against causative bacteria, urinary concentration and bacteriological effect
There were 8 out of 10 strains which showed higher value than MIC of CFS in urinary concentration. Among these 8 strains, 5 showed vanishment of P. aeruginosa. The disapperance rate of P. aeruginosa was 62.5% in cases which showed higher value than MIC of CFS in urinary concentration. However, in the patients with abnormal kidney function, there was no case of urinary concentration enough to secure a bacteriological effect with 250 mg of administration.
5) Side effect
Three cases (27.2%) showed elevated GOT and GPT.
