Laboratory and clinical studies on cefotiam (SCE-963) were carried out and the following results were obtained.
1. The biliary excretion of cefotiam in the perfusing isolated liver of rat was strikingly higher than other cepharosporins (cephalothin, cephaloridine, cefazolin, cephacetrile, ceftezol, cephalexin, cephradine, cefatrizine).
2. Cefotiam was given to 6 patients with moderate or severe biliary tract infection (5 patients) and respiratory tract infection (1 patient). Responses were excellent in 2 patients, good in 3 and poor in 1, As a side effect, anemia was observed in 1 case.
