Abstract
Cefadroxil, a new oral cephalosporin antibiotic, was investigated for its β-lactamase stability and antibacterial activity against β-lactamase-producing strains of Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, P. morganii, P. vulgaris, Citrobacter freundii, Enterobader cloacae and Serratia marcescens. Cefadroxil was very stable to penicillinase and its antibacterial acivity against E. coli, K. pneumoniae and P. mirabilis was not affected by production of high penicillinase activity in those organisms. The antibacterial activity of cefadroxil against E. coli, P. morganii, P. vulgaris, C. freundii, S. marcescens and Ent. cloacae was lowered with increasing cephaloeporinase activity in those organisms. The results indicated that cefadroxil was similar in anti-bacterial activity and β-lactamase stability to cephalexin.
