Abstract
Cefadroxil (CDX), a new cephalosporin antibiotic for oral administration, was investigated on its general pharmacology.
1. CDX was given orally in mice at a dose of 4, 000mg/kg, and no effect of the drug was observed on ether anesthesia, pentobarbital sleep, pentetrazol convulsions, analgesic action and muscle-relaxing action.
2. CDX was investigated in situ and in vitro on the effects upon autonomic nervous system. No effect of the drug was observed on blood pressure, respiration and ECG at a dose of 100mg/kg. Inhibitory action in vitro was generally observed on isolated organs at a concentration of more than 500μg/ml.
3. CDX was given in rats for 7 days at a dose of 100mg/kg, and no influence was noted on urinary excretion and its electrolytes.
