EVALUATION ON CEFOPERAZONE (T-1551)

Abstract

Serum concentration was determined in three aged patients after intramuscular injection of 1g of cefoperazone (CPZ, T-1551). Serum concentration ranged from 61 to 87.5μg/ml at a peak level, and decreased slowly to 24.5-37μg/ml at 6 hours after injection.
Clinical evaluation was performed on 2 patients with septicemia, 4 patients with UTI, 2 patients with pneumonia, 1 patient with decubital infection and 9 patients with hepatobiliary infection. Satisfactory response was obtained 1 patient with septicemia, 4 with UTI, 1 with pneumonia, 1 with decubital ulcer and 8 with hepatobiliary infection. CPZ revealed revolutional clinical effect on patients with ascending hepatobiliary infections, who had been undertaken hepatojejunostomy for carcinoma of bile duct.
Prothronbin prolongation and hemorrhage were observed in one patient with obstructive jaundice during the course of CPZ therapy.