Abstract
The nephrotoxic potential of compound 6059-S was evaluated in rabbits after intravenous administration of 500 and 2, 000 mg/kg (ear vein).Effects on plasma chemistry parameters were determined. Histological examinations of kidney tissues of all animals were performed after 48 hours.Four rabbits were used at each dose level, and comparative studies were performed using several other injectable cephalosporins.
Compound 6059-S caused no nephrotoxicity after intravenous dosing.Compound 6059-S produced significantly less nephrotoxicity than cefazolin, a compound which has not produced significant nephrotoxicity in human chemotherapy.Intravenously, 6059-S was shown to be as minimally nephrotoxic as cephalothin, a compound which also has not shown nephrotoxicity in humans.
Comparison of the nephrotoxicity among diverse cephalosporins showed as follows, in male rabbits; CTM>CEZ>CTX>CMZ=CET=6059-S, in female rabbits;CEZ≥CTM>CMD=CET=6059-S.
