Abstract
The in vitro activity of KW-1070 (fortimicin), a new aminoglycoside, against anaerobic bacteriawas compared with of gentamicin. The antimicrobial spectrum of KW-1070 was similar to that ofgentamicin. MIC values of KW-1070 to anaerobic bacteria (B. fragilis, B. thetaiotamicron, F. varium, F. nucleotum, C. difficile, P. prevotii, etc.) ranged from 6.25 to> 1, 600 μg/ml. Gram-positive bacteria (MIC: 6.25-400 μg/ml) were more sensitive to KW-1070 than gram-negative bacteria (MIC: 12.5-> 1, 600 μg/ml).
