Abstract
KW-1070, a new aminoglycoside antibiotic was bacteriologically evaluated. The results are summarized as follows:
1) The antimicrobial spectrum and activity of KW-1070 were similar to those of amikacin, exceptthe activity was less active than that of amikacin against Pseudomonas aeruginosa.
2) KW-1070 was effective against bacteria capable of producing aminoglycoside-inactivating enzymesexcept for AAC (3)-I and therefore, it was active against various aminoglycoside-resistant strains.
3) In sensitivity test of clinical isolates, the antibacterial activity of KW-1070 was similar orslightly less active in comparison with amikacin. KW-1070-resistant strain was only rarely observed.
4) KW-1070 showed bactericidal activity, being superior to that of amikacin.
5) On the protective effects for experimental infections of various aminoglycoside-sensitive bacteria, KW-1070 showed similar effect to amikacin. Furthermore, KW-1070 was effective both in aivi andin vitro in experimental infections due to various aminoglycoside-resistant bacteria including amikacinresistant strain.
