1982 Volume 30 Issue 11 Pages 1349-1360
Norfloxacin (AM-715), a new oral antibacterial agent, was evaluated clinically for the patients with urethritis and the following results were obtained.
(1) Thirty-five patients with gonococcal urethritis and 25 patients with non-gonococcal urethritis were administered at daily dose of 600mg divided 3 times for a duration of 3 to 7 days. Overall clinical efficacy rate was 94.3%(33/5) in patients with gonococcal urethritis and 83.3%, (20/24) in patients with non-gonococcal urethritis except for one case.
(2) MIC values of AM-715 against clinical isolated gram-positive coccus were distributed from 0.2μg/ml to 25μg/ml. These MIC values were superior to those of NA and PPA.
(3) Side effect was observed in only one case as complaint of diarrhoea. It was concluded that AM-715 was an useful agent for the treatment of urethritis.
