THE COMBINATION EFFECT OF TA-058 AND AMINOGLYCOSIDE ANTIBIOTICS
1984 Volume 32 Issue Supplement2 Pages 152-157
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1984 Volume 32 Issue Supplement2 Pages 152-157
The combination effects of TA-058 and several aminoglycoside antibiotics (AGs) were examined and the results obtained are summarized as follows:
1. S. aureus 209-P JC-1 and E. coli. NIHJ JC-2 were both sensitive to TA-058 and AGs tested alone but combinations of TA-058 with each AGs produced only an additive or a weak synergistic effect (Fig. 1).
2. S. marcescens, P. vulgaris, P. rettgeri and P. aeruginosa were not always sensitive to TA-058 or AGs, however, combinations of the two drugs gave a moderate or a marked synergistic effect (Fig 1).
3. The combinations of TA-058 and AGs were synergistic for 16 strains (80%) of 20 clinical isolates of P. aeruginosa (Table 1).
4. The synergistic effect against clinically isolated P. aeruginosa was most potent with combination of TA-058/gentamicin (GM) and followed by TA-058/tobramycin (TOB), TA-058/dibekacin (DKB) and TA-058/amikacin (AMK)(Table 1).
5. The combination of TA-058/AMK also exhibited a marked in vivo synergistic effect in an experimental infection of mice with P. aeruginosa (Table 2).
