1984 Volume 32 Issue Supplement2 Pages 166-170
The changes of microflora in rats feces were studied in the course of subacute toxicity tests for TA-058 (5 week and 3 month periods). The changes were also examined in rats given the drug daily for 10 days.
In all of dosage groups tested, administration of TA-058 decreased the numbers of the drug sensitive species, Streptococcus faecalis group and Staphylococci, in microflora. However, the numbers of Enterobacteriaceae and Bacteroides almost remained unchanged or moderately increased. Pseudomonas aeruginosa was not detected in all feces. Among Enterobacteriaceae, Klebsiella sp. was found to be most dominant species, but Escherichia coli was rarely detectable one. Almost of all Proteus sp. isolated fromTA-058 administered rats were identified as indole-positive species.
In rats given the drug daily for 10 days, the numbers of Escherichia coli decreased 1 to 3 days after the drug administration and began to increase imediately after the withdrawal of the drug. On the other hand, the numbers of Klebsiella sp. increased for 4 to 7 days after the administration and gradually decreased.
he changes of fecal flora caused by the administration of TA-058 (5 weeks) were almost recovered to normal flora levels 4 weeks after the discontinuation of the drug administration.
