1984 Volume 32 Issue Supplement2 Pages 196-202
(1) TA-058, a new parenteral penicillin antibiotic, was prescribed to 9 patients with bacterial pneumonia and one with bacterial meningitis. TA-058 was administered 1 to 4 gram twice a day by intravenous drip-infusion from 2 to 18 days respectively. Causative organisms isolated before administration of TA-058 were S. pneumoniae in 2 cases, S. aureus, S. viridans and K. pneumoniae in each one case and unknown in 4 cases with bacterial pneumonia and in one case with meningitis.
Clinical efficacies of TA-058 were excellent in 2 cases, good in 4 cases including one case with meningitis, fair in 2 cases and poor in 2 cases.
And the case of adverse effects due to TA-058 were not observed but transient elevations of serum transaminase or serum alkaline-phosphatase were noticed in three cases during TA-058 therapy.
(2) The pharmacodynamic effect of TA-058 on plasma glucose was studied.
Two gram of TA-058 with 20 ml of saline was administrated intravenously within 5 minutes to four diabetic patients who were controlled with diet only before breakfast, and serum or plasma levels of TA-058, glucose, insulin, glucagon and cortisol were measured before and after 15, 30, 60, 90 and 120 minutes TA-058 administration.
Serum concentrations of TA-058 were 181.9μg/ml after 15 minutes TA-058 administration and 49.3μg/ml after 120 minutes. No remarkable changes were observed before and after TA-058 administration on the concentration of glucose, insulin, glucagon and cortisol.
These results were suggested that TA-058 was considered to be a useful penicillin antibiotic in the treatment of infectious disease.
