1984 Volume 32 Issue Supplement2 Pages 203-205
Clinical investigation on TA-058, a new derivative of amoxicillin, was performed and the results obtained were as follows:
Among 6 patients treated with TA-058 via drip infusion twice daily (2-4g) for their respiratory tract infections due to Haemophilus influenzae including a β-lactamase producing strain, 4 cases resulted in bacteriologically eradicated. In the case with β-lactamase producing strain (MIC; 25 μg/ml) the causative organism decreased from 108 cfu/ml to 108 cfu/ml. The remaining case (MIC;0.1μg/ml) showed the change to Pseudomonas aeruginosa as causative agent. The clinical results were effective in 5 cases. No adverse effect clearly due to this drug was observed except one case in which GOT and GPT elevated transiently during the administration.
From the above results, it was suggested that TA-058 is useful for respiratory tract infections caused by Haemophilus influenzae.
