CLINICAL STUDIES ON TA-058 IN THE RESPIRATORY TRACT INFECTION

Abstract

Clinical efficacy and adverse effects of TA-058, a new penicillin antibiotic, were studied in 14 patients with the respiratory tract infections receiving 1.0 to 2.0g b. i. d. by drip infusion.
Among them, 8 cases were lower respiratory tract infection, 5 cases were pneumonia and 1 case was pulmonary empyema.
The obtained results were excellent in 2, good in 10 and fair in 2 cases, thus producing moderate to marked clinical improvement in 85.7% of cases studied.
As for abnormal laboratory findings, slight elevations of GPT and Al-P were seen in 1 case. These findings improved shortly after cessation of the drug.