PHARMACOKINETIC AND CLINICAL STUDY IN AGED PATIENTS ON TA-058
1984 Volume 32 Issue Supplement2 Pages 281-286
Details
1984 Volume 32 Issue Supplement2 Pages 281-286
Pharmacokinetic study of TA-058 in 4 aged patients with normal serum creatinine levels was performed. Serum concentration of TA-058 by bolus intravenous injection of 1 g at 1/12, 1/2, 1, 2, 4, 6 and 8 hours after injection were 112, 63.4, 43.6, 31.7, 17.6, 9.0 and 5.4μg/ml respectively. Serum half life of β phase was 2.4 hours. Area under the curve was 209.9 hr·μg/ml. Urinary recovery rate during first 8 hours was 52.3 %.
TA-058 was given in 7 aged patients (4 with pneumonia, 1 with acute bronchitis, 1 with erysipelas and 1 with U. T. I.). Satisfactory response was obtained in 5 patients by administration of TA-058 of 0.5 to 1 g on every 12 hours. Non adverse effect was noted in every patients.
