1984 Volume 32 Issue Supplement2 Pages 314-321
Laboratory and clinical studies on TA-058 were performed and the following results were obtained.
1) Minimum inhibitory concentration (MIC) of TA-058 was determined in 136 clinical isolates compared with those of PIPC. TA-058 showed an antibacterial activity similar or inferior to PIPC against E. coll. K. pneurnoniae, Serratia, P. aeruginosa and Proteus genus.
2) Clinical trial of TA-058 was performed in 23 patients, 18 with respiratory tract infections, 3 with biliary tract infections, 1 with urinary tract infection and 1 with fever unknown origin. Responses were excellent in 2, good in 14, fair in 3, poor in 3 and unknown in 1. Effective rate was 72.7%. Two patients showed the following adverse reactions, nausea and elevation of GOT, ALP in one patient, elevation of GOT, GPT and leukopenia in another one.
