CLINICAL STUDY OF TA-058
1984 Volume 32 Issue Supplement2 Pages 322-328
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1984 Volume 32 Issue Supplement2 Pages 322-328
The authors report on the results of their clinical investigations of TA-058, a new semisynthetic penicillin antibiotic.
The antibacterial activity of TA-058 was compared to that of ampicillin (ABPC) and piperacillin (PIPC) in a total of 150 clinically isolated strains of S. aureus, E. coli, Citrobacter, Klebsiella, Enterobacter, Serratia, Psudomanas and Proteus.
TA-058 exhibited greater antibacterial activity against P. mirabilis than did ABPC and PIPC, and it was proved to be almost the same or slightly weak as PIPC against other strains.
TA-058 was then administered to a total of 17 patients, among whom there were 13 cases of respiratory tract infections (R. T. I.), one case of septicemia and 3 cases of urinary tract infections (U. T. I.).
Results obtained were good in 10 (77.0%) out of 13 R. T. I., good in the sole case of septicemia and U. T. I. also showed good in all cases.
No side effect nor adverse reaction of the drug observed in all cases.
