1984 Volume 32 Issue Supplement2 Pages 607-613
1), Clinical effect of TA-058 was studied in 16 patients with complicated urinary tract infections.
2) The clinical results were excellent in 3 cases, moderate in 7 cases and poor in 6 cases. The effective rate was 63%.
3) On bacteriological evaluation TA-058 was the relatively good activity against Pseudomonas genus.
4) Serum levels and urinary excretion of TA-058 were measured in 4 patents. The serum level attached to the peak at 30 minutes and the urinary recovery rate up to 4 hours reached 50%.
5) Tissue concentrations of TA-058 to kidney (one case), bladder (2 cases) and ureter (one case) were investigated. After the intravenous bolus injection of 1 g, the concentrations achievedin kidney 67.5μg/g at 30 minutes, 122.5 μg/g at 60 minutes, in bladder 72.5μg/g and 69.0μg/g at 30 minutes and 135.0 μg/g and 41.5 μg/g at 60 minutes, in ureter 24.5 μg/g at 60 minutes.
6) No side effects were observed in all cases.
