1984 Volume 32 Issue Supplement2 Pages 614-620
TA-058 is a new semisynthetic derivative of amoxicillin. Twenty-seven patients suffering from genitourinary tract infections were treated with 1 or 2 g of TA-058, intravenously twice daily for days, and the clinical efficacy and safety were evaluated. Of these 27 patients, 3 had uncomplicated urinary tract infections (all with acute pyelonephritis), 13 complicated urinary tract infections (2 with chronic pyelonephritis and 11 with chronic cystitis) and 11 infections of the male genital organ (4 with acute epididymitis and 7 with acute prostatitis). An excellent response was obtained in 100 % of the patients with acute pyelonephritis, and excellent plus moderate response in 54% of the patients with complicated urinary tract infections and in 100 % of the patients with infections of the male genital organ. Two patients of diarrhea were noted as an adverse reaction. No additional laboratory abnormalities were found except a transient elevation of alkaline phosphatase in one patient. The administration of this drug was shown to be useful in managing genitourinary tract infections.
