1984 Volume 32 Issue Supplement2 Pages 77-89
In vitro antibacterial activity of a new semisynthetic penicillin, TA-058, was tested and the following results were obtained:
1) Like ABPC, TA-058 showed a broad spectrum activity against gram-positive and gramnegative bacteria and it was as active as SBPC against P. aeruginosa.
2) Antibacterial activity of TA-058 against clinical isolates of E. coli, P. mirabilis and H. influenzae was superior to those of reference penicillins.
3) Examination of the effect of various factors on antibacterial activity of TA-058 revealed that the activity was almost not affected by the factors except for the inoculum size of P. aeruginosa.
4) TA-058 had a similar strong bactericidal activity to ABPC and SBPC. Lytic form of the bacterial cells (E. coli NIHJ JC-2) were observed by microscopic examination at concentrations more than 12.5μg/ml of TA-058.
5) TA-058 was hydrolyzed by penicillinases of gram-negative rod bacteria.
