1984 Volume 32 Issue Supplement2 Pages 90-98
In vivo efficacy of TA-058, a new parenteral semisynthetic penicillin, was examined in comparison with ampicillin (ABPC), amoxicillin (AMPC), carbenicillin (CBPC), sulbenicillin (SBPC) and piperacillin (PIPC) to see if its broad antibacterial spectrum in vitro is reflected in its antibacterial effects against experimental infections in mice. TA-058 was more effective than the reference drugs against intraperitoneal infections by various gram-negative bacterial species. However, TA-058 was inferior to ABPC and AMPC against infections by gram-positive bacteria.
Furthermore, on the abscess caused by subcutaneous infection with S. aureus or S. hemolyticus, TA-058 exhibited greater suppressive effects than ABPC. TA-058 showed more potent therapeutic effects than PIPC and CBPC against experimental pneumonic infections induced by inhalation of K. pneumoniae B-54 and against ascending urinary tract infections by P. mirabilis or E. coli in mice.
