STUDIES ON THE ENHANCEMENT OF ANTIMICROBIAL DEFENCE ACTIVITIES OF AC-1370 AND ITS DERIVATIVES

Abstract

A new antibiotics, AC-1370 (AC) shows in vivo antimicrobial activities other than in vitro antibiotic activities. Therefore we investigated host defence enhancing activities of derivatives of AC and hydrolized AC (H-AC).
Although there was no increasing of host defence activities with the pretreatment of 0.1mg/kg of H-AC in the immunosuppressed mice infected with E. coli, bactericidal activities of peritoneal exudate cells were significantly increased with the treatment of H-AC.
It was also noted that enhancement of in vitro NBT reduction activities of human peripheral leukocytes with addition of 100μg/ml of H-AC.
These results were indicated that AC-1370 had enhancing activities of neutrophilic function under certain experimental conditions.