ACTIVITIES OF AC-1370 TO AUGUMENT IMMUNOLOGICAL FEATURES OF THE LYMPHOCYTE AND BACTERIOCIDAL EFFECT OF THE NEUTROPHILE

Abstract

Activities of AC-1370 to augument immunological features of the lymphocyte and the bacteriocidal effect of the neutrophile were evaluated in 5 patients who received surgery at the Second Department of Surgery, School of Medicine, Chiba University. AC-1370 was given intraveneously 4 gram daily for one week. The activities of the lymphocyte and the neutrophile were tested at the time of before and after AC-1370 treatment. Immunological activities of the lymphocyte in terms of PHA-P and Con A responses, and ADCC activity did not show any change by the treatment. Proportion of the subpopulation of the lymphocyte in terms of T cells, B cells, and IgG Fat⁺ T cells did not show any change, either. The bacteriocidal activity of the neutrophile decreased significantly one week after operation in the patients who did not receive AC-1370, however, decrease in the activity was not observed in the patients receiving AC-1370. These results suggested that AC-1370 have an ability to augument the bacteriocidal effect of the neutrophile.