1984 Volume 32 Issue Supplement9 Pages 237-245
AC-1370, a new broad spectrum cephalosporin antibiotic, was evaluated in vitro against a variety of human pathogens.
The activity of AC-1370 was equivalent to that of cefazolin against E. coli, Klebsiella and Proteus. Against P. aeruginosa it was more effective than latamoxef and cefmetazole and less effective than cefoperazone.
AC-1370 was administered to five patients 2 g per day for 7 to 11 days. They have been suffered from pneumonia, cholecystitis, pyelonephritis, or biliary tract infection. Their clinical course showed that AC-1370 was effective to all their diseases.
Neither clinical side effect nor abnormal laboratory finding was found.
