1984 Volume 32 Issue Supplement9 Pages 30-41
Bacteriological evaluation to anaerobes was made on AC-1370, a new cephem antibiotic as compared with other cephems, and the following results were obtained.
1) AC-1370 showed a broad antianaerobic activity, its activity against gram-positive cocci was inferior to that of CPZ, CFX or CEZ, and against gram-negative rods was the activity of AC-1370 equal to or somewhat inferior to that of CEZ, CPZ or CFX. Among the various species of anaerobes examined, AC-1370 showed a good activity against P. micros and C. ramosum, and a less activity against B. fragilis group, E. lentum and C. difficile in general.
2) AC-1370 was hydrolyzed by (3-lactamase derived from B. fragilis and B. bivius, however its hydrolysis rate was less than that of CMX.
3) AC-1370 showed superior therapeutic effect than CMX against experimental polymicrobial infection in mice caused by E. coli and B. fragilis.
4) Appearance of C. difficile in caecal contents was not observed when AC-1370 was administered to mice at a dose of 2mg/mouse for 7 days, contrary to the cases of CTX and CFX.
