1984 Volume 32 Issue Supplement9 Pages 42-59
Bacteriological evaluation was attempted on AC-1370, a new cephalosporin, with cefazolin (CEZ), cefoperazone (CPZ), ceftazidime (CAZ) and carbenicillin (CBPC) as the control drugs.
AC-1370 showed a broad antibacterial spectrum against gram-positive and gram-negative bacteria. Its antibacterial activity was equivalent to that of CEZ and inferior to that of CPZ and CAZ. Against P. aeruginosa, however, the antibacterial activity of AC-1370 was equivalent to that of CPZ.
Studies were also conducted on the influence of various experimental conditions on antibacterial activity of AC-1370, and it was recognized that the drug is hardly affected by pH of culture or addition of horse serum, and slightly affected by inoculum size.
Studies on the mode of the antibacterial activity of AC-1370 revealed its marked bactericidal action against any one of the bacterial strains used.
As to the therapeutic effect in experimental intraperitoneal infections in mice, that of AC-1370 against E. coli were superior to that of CEZ and inferior to that of CPZ and CAZ. Against K. pneumoniae, AC-1370 was inferior to CPZ and CAZ. Against P. aeruginosa, AC-1370, although inferior to CAZ, was superior to that of CPZ and CBPC.
