1984 Volume 32 Issue Supplement9 Pages 60-67
The therapeutic efficacies of AC-1370, a new cephem, were compared with those of cefoperazone (CPZ) and ceftazidime (CAZ) in experimental infections in mice, in an attempt to find out the activation on host defense mechanisms. Against experimental intraperitoneal infections caused by P. aeruginosa, the efficacy of AC-1370 was equivalent or superior to that of CPZ. The MICs of AC-1370 against the test strains, however, were inferior to those of CPZ. Against experimental urinary tract infections, the efficacy of AC-1370 was superior to that of CPZ and inferior to that of CAZ.
Serum and organ levels of AC-1370 in infected mice were more durable than those of CPZ and CAZ.
The relationship between AC-1370 and neutrophils was investigated. As a result of the therapeutic efficacy of AC-1370 on experimental infection in compromised mice, the efficacy of AC-1370 was more dependent on the neutrophils than that of CPZ. As to the migration and phagocytosis by neutrophils in drugtreated mice, AC-1370 activated the function of neutrophils.
