1984 Volume 32 Issue Supplement9 Pages 74-93
Bacteriological evaluation was attempted on AC-1370, a new cephalosporin, with cefazolin (CEZ), cefoperazone (CPZ), cefotaxime (CTX) and carbenicillin (CBPC) as the control drugs.
AC-1370 showed a broad antibacterial spectrum against gram-positive and gram-negative bacteria. Its antibacterial activity was equivalent to that of CEZ and inferior to that of CPZ and CTX. Against P. aeruginosa, however, the antibacterial activity of AC-1370 was superior to CEZ, CTX and equivalent to CPZ.
Studies were also conducted on the influence of various experimental conditions on antibacterial activity of this agent, and it was recognized that the drug is hardly affected by pH of culture or addition of horse serum, and slightly affected by inoculum size.
The drug was highly stable to all types of β-lactamase as classified by Richimond except for that of P. vulgaris.
As to the therapeutic effects in experimental infections in mice, that of AC-1370 against E. coil were superior to that of CEZ and inferior to that of CTX and CPZ. Against to K. pneumoniae, AC-1370 was also inferior to CPZ and CTX. Against P. aeruginosa, AC-1370 was superior to CBPC, CTX and CPZ.
