AC-1370のヒト多核白血球スーパーオキサイド (O2-) 産生能に及ぼす影響について

熊坂 義裕; 中畑 久; 平井 裕一; 今村 憲市; 武部 和夫

doi:10.11250/chemotherapy1953.32.Supplement9_94

EFFECT OF AC-1370 ON SUPEROXIDE ANION (O₂^-) PRODUCTION BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES

YOSHIHIRO KUMASAKA, HISASHI NAKAHATA, YUICHI HIRAI, KENICHI IMAMURA, KAZUO TAKEBE

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JOURNAL FREE ACCESS

1984 Volume 32 Issue Supplement9 Pages 94-97

DOI https://doi.org/10.11250/chemotherapy1953.32.Supplement9_94

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Abstract

Effect of AC-1370, a new semisynthetic cephalosporin antibiotic, on superoxide anion (O₂^-) production by human polymorphonuclear leukocytes (PMNs) was examined, and compared with that of cefazolin (CEZ), ceftizoxime (CZX), cefbuperazone (CBPZ).
There has been observed a direct effect on O₂^-production by PMNs with both AC-1370 and CEZ, but not with CZX or CBPZ either, under the condition where 4×10⁵ PMNs were stimulated with 200μg of each antibiotic. And this effect of AC-1370 was stronger than that of CEZ.

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