1984 Volume 32 Issue Supplement9 Pages 831-836
In order to study oral surgical application of AC-1370, fundamental and clinical investigations were carried out and the following results were obtained.
1) Rabbits were intravenously injected with AC-1370 at a dose of 33 mg/kg over a period of 2 hours. The levels of serum and submandibular gland attained to maximum at the end of injection, showing 76.35±6.017 pern1 and 6.69±0.607 peg respectively. The levels of tongue, gingiva, parotid gland, and cervical lymphonodi attained to maximum at 2 hours and 15 minutes from the begining of injection, showing 16.24±0.668μg/g, 30.23±4.770μg/g, 13.52±1.476μg/g and 17.26±0.406μg/g respectively. The ratios of such peak levels vs. peak serum level were in the following order: gingiva< cervical lymphonodi< tongue< parotid gland< submandibular gland.
2) AC-1370 was intravenously administrated to 15 cases with infection in oral region at daily dose of 1 to 2 g for 1 to 7 days. The clinical effectiveness rate was 93%.
3) Side effects were observed in 2 cases, which consisted of headache in one case, and rash and nausea with decrease of blood pressure in one case. No abnormal laboratory findings were noted.
