1984 Volume 32 Issue Supplement9 Pages 837-842
Clinical and laboratory studies of AC-1370, a new synthetic cephalosporin, were carried out and the following results were obtained.
AC-1370 was administered to 10 patients of acute infections of oral and maxillofacial regions consisting of 7 cases of mandibular ostitis, 2 cases of cellulitis of floor of mouth and 1 case of cellulitis of cheek, at a daily dose of 2 g for 3-7 days. The results based on the points determined byithe criteria recommended by the Japanese Society of Oral Surgery revealed excellent in 2 cases, good in 6 cases, poor in 2 cases. No side effect was observed.
The sensitivity was determined by the plate dilution method with 16 strains of anaerobic Streptococcus and 23 strains of aerobic Streptococcus that were isolated from acute infections of oral and maxillofacial resions. The growth of 50% of Streptococcus was inhibited at concentration of less than 6.25μg/ml and all of the strains was inhibited at concentration of less than 25μg/ml.
