1986 Volume 34 Issue 8 Pages 677-681
An experimental uterine infection model was prepared in mice using Escherichia coli strain 444.
The uterine infection was distinctly caused by E. coli in five-week-old female mice untreated withprogesterone, The induction of uterine infection with this organism was possible by the inoculation of ca. 105 cells per mouse or more. This infection model continued for at least 7 days, but did notturn into sepsis.
Against the uterine infection produced by E. coli, the corresponding therapeutic efficacy to the dose of ofloxacin and ciprofloxacin were observed.
Thus, the preparation of uterine infection caused by E. coli was successful. It seemed that thismodel can utilize as one of the in-vivo evaluation model to antibiotics.
