1986 Volume 34 Issue 8 Pages 682-687
Comparative studies were made on mice of ddN and ICR strains on the therapeutic effect of antibiotics administered.
MLD of Escherichia coli C 11 inoculated intraperitoneally was smaller in ICR strains, representing higher susceptibility and the same results were observed in experimental infection with strains of Serratia marcescens and Pseudomonas aeruginosa.
ED50 values of ampicillin, carbenicillin, sulbenicillin, cefazolin, gentamicin and dibekacin obtained in ICR strains were generally smaller than those in ddN strains against the same infectious dose of E. coli C11.
Pharmacological examination revealed that, in contrast with normal mice, a higher serum level of antibiotic was attained in infected mice of ICR strain.
The above results indicate that, in assessing the in vivo antibacterial effect accurately, pharmacological properties of antibiotics in infected mice should be investigated with the same strain as was used for efficacy tests.
