Abstract
We conducted a clinical study on cefpirome (CPR), a new cephalosporin, in the surgical field.
The drug was given at 1.0 g a day for 1-14 days to 10 patients with surgical infections, 5 with secondary infection of the operative wound, 3 with intraabdominal abscess, and 2 with cervical abscess afteresophagectomy. The results were as follows.
1. Eight cases were clinically evaluated, the response being good in 6 and fair in 2.
2. Bacteriologically, CPR proved to have high antibacterial activity against Gram-negative bacilli and anaerobs.
As a whole, 12 strains of 17 were eradicated and the rate being 70.6%.
3. As a side effects, allergic vasculitis was found in one case.
But when administration was discontinued, the symptom improved in a few days.
