Mechanism of renal excretion of biapenem in dogs

Abstract

Mechanism of renal excretion of biapenem (BIPM), a new carbapenem antibiotic, was investigated in dogs using stop-flow analysis. In the stop-flow studies, dogs were cannulated into the ureter for collection of urine, into the vein for constant infusion of BIPM, mannitol, creatinine and p-aminohippuric acid, and into the artery for blood sampling.
No specific peak of BIPM was recognized in the phase of p-aminohippuric acid excretion nor in the entire phase of Na⁺/K⁺reabsorption in dogs. After pretreatment of probenecid, the peak of paminohippuric acid disappeared while the stop-flow pattern of BIPM remained virtually unchanged. These findings suggested that the renal excretion of BIPM took place mainly through glomerular filtration in dogs.