1994 Volume 42 Issue Supplement4 Pages 285-289
The penetration of biapenem (BIPM)(a new carbapenem) was studied with regard to its levels in pleural fluid and serum in patients with pleural effusion.
The subjects of this study were four patients with pleural effusion (carcinomatous pleurisy 3, pleural effusion of unknown cause 1). 300mg of BIPM was administered by drip infusion over one hour.
Then the levels of BIPM in pleural fluid and serum were measured by a method of bioassay.
The peak levels of pleural fluid for four cases were from 4.4 to 10.8μg/ml between 30 minutes and one hour after drip infusion. The mean peak level was 8.0±3.2μg/ml after 30 minutes d.i.v. The peak levels of serum for four cases were between 15.7 and 23.1μg/ml immediately after drip infusion.
The mean peak level of serum was 18.7±3.3μg/ml.
The AUC (area under curve) of pleural fluid was 35.5μg·Ehr/ml (24.1-42.0), and that of serum was 34.6μg·Ehr/ml (27.5-1.1). The mean T1/2 of pleural fluid was 3.2 hours (2.6-5.7), while that of serum was 1.5 hours (1.1-2.0). Based on the above results, the pleural fluid/serum ratio of Cmax and AUC of BIPM were determined to be 42.8% and 103%, respectively. This study revealed that the penetration of BIPM into pleural fluid was excellent among β-lactam agents.
