1994 Volume 42 Issue Supplement4 Pages 559-564
The clinical effects of biapenem (BIPM) on infectious diseases in obstetrics and gynecology and the transferability of BIPM in female genital tissues were assessed. Concentrations of BIPM in the blood and female genital organs after 300mg single intravenous drip infusion of this drug were measured. Blood concentrations in the uterine artery at 90-120 minutes after the treatment were respectively found to be 3.2-6.2μg/ml. Tissue concentrations in the uterus and adnexa ranged from 0.5-2.2μg/ml.
BIPM was administered to 5 patients with intrauterine infections, 4 with adnexitis, 8 with pelvic infections and 2 with bartholin's abscess. The overall clinical efficacy was excellent in 3 patients, good in 11 and poor in 2. The overall efficacy rate was 87.5%(14/16).
As an adverse reaction, eruption was observed in only one patient, and there were no abnormal clinical laboratory data.