Pharmacokinetic and clinical study of biapenem in obstetric and Gynecology

Abstract

Biapenem (BIPM), a newly developed carbapenem antibiotic, was evaluated for its tissue penetration into female genital organs and its clinical usefulness, with the following results.
The intravenously administered BIPM, a single drip infusion (60 minutes) of 300mg, showed the fast and good penetration to the tissues (endometrium, myometrium, cervical canal, raginal portion of the cervix, uterine tube and ovaries): the peak concentration in the cubital vein and uterine artery were 4.46 and 4.42μg/rnl, respectively. Maximum concentrations in genital tissues were 1.23 3.52μg/g.
BIPM was administered to 5 patients, 1 with infected abortion, 2 with endometritis and 2 with salpingitis at doses of 150-300mg twice a day for 4 to 8 days. The clinical response was good in all cases. 2 and 1 of the 5 patients in whom the bacteriological effects weree valuated showed bacterial elimination, partially elimination, respectively. In other 2 patients, one patient was superinfection and the other patient was unknown bacteriologically. There were no specific side effects or abnormal values of clinical laboratory tests.