1994 Volume 42 Issue Supplement4 Pages 591-594
We studied biapenem (BIPM), a new carbapenem antibiotic, for its clinical efficacy and transfer into serum and tissues, and obtained the following results.
1) After 30 min intravenous administration of 0.3g of BIPM, the serum concentration in the uterine artery was almost equal to that in the elbow vein and peak level was around 24-26μg/ml in 18 minutes. Favorable results were also obtained for concentrations in both adnexal and uterine tissues studied.
2) The clinical response in 19 patients with gynecological infections was excellent in 4, good in 15, the efficacy rate being 100%.
3) No side effects or abnormal laboratory findings were observed.
This drug showed excellent efficacy and high safety in the treatment of gynecological infections.